The research team from Monash Institute of Pharmaceutical Sciences in Melbourne discovered how to change the way that the adenosine receptor, the heart-protecting molecule, works and reacts when administered with adenosine contained in heart drugs.
“We discovered that there is a totally different way of activating these proteins than was previously thought possible. You can change the body’s own rules if you get the molecule right,” Christopoulos said.
The professor added that almost half of all medications available target protein receptors, so this method could be used to make more effective drugs for many conditions, including schizophrenia and diabetes. His future goal is to continue the research and to develop drugs with minimum or no side-effects.
Dr. Christopoulos is specializing in alternative, low-cost pharmacology and he is already considered as one of the leading pharmacists worldwide. He has also won two important awards, the John Jacob Abel Award and the Michael Rand Medal.